Endocrine Abstracts

Introduction: Uncontrolled hyperglycemia in diabetes is a common cause of microvascular complications, including diabetic nephropathy (DN). Despite improvements in the management of type 2 diabetes (T2DM), diabetic nephropathy is still associated with high morbidity and mortality. The objective of our study is to evaluate the predictive factors of DN in adults with T2DM in order to prevent its development.Patients and Methods: A retrospective study, incl...

Introduction: Acromegaly is the set of clinical manifestations induced by chronic exposure to an endogenous excess of growth hormone (GH). Most often, acromegaly is related to GH production by a pituitary adenoma. It may be associated with neuroendocrine tumors of the pancreas as part of multiple endocrine neoplasia type 1 (MEN1). Herein, we described a tumor mimicking a carcinoma of the Ampulla of Vater in a patient with acromegaly.Observation: A 54-yea...

Introduction: Chromosomal abnormality 47, XYY, despite being present in approximately 1 in 1000 newborn boys, remains less known phenotypically and more than 85% of men are never diagnosed. Males with 47, XYY syndrome are described to be phenotypically normal. They present often a developmental delay, behavioral difficulties and learning disabilities that may be associated with accelerated growth rate and taller stature in adulthood. Endocrine disorders, especially pubertal de...

Introduction: Hyperpigmentation is a clinical sign that can be associated with different endocrine disorders. It is commonly seen in Addison’s disease and has rarely been reported in Graves’ disease. The exact physio pathological mechanism of this sign is not well established in hyperthyroidism. We describe two cases of Graves’ disease accompanied by diffuse hyperpigmentation.Case report: Case 1 was a 63-year-old female ad...

Introduction: 11-Beta-hydroxylase deficiency (11β-OHD) is the second most common cause of congenital adrenal hyperplasia. It leads to the accumulation of steroids precursors prior to the enzyme defect, notably 11-deoxycorticosterone (DOC), leading therefore to low renin hypertension and hypokalemia. Hence, patients with 11β-OHD are reportedly protected from adrenal crisis. Here, we report a case of a male with 11β-OHD presenting with acute adrenal insufficiency....

Introduction: Pituitary neuroendocrine tumors (PitNET) represent 15.5% of primary brain tumors and they can be clinically functioning or non-functioning. Although they are mostly benign, PitNET may be invasive in 30-45% of cases and aggressive in at least 15%. Here, we report the case of a patient who presented a multiple and rapid recurrence of a non-functional pituitary macroadenoma.Observation: A 42-year-old man was admitted initially for headaches, m...

Introduction: Klinefelter syndrome is the most prevalent male chromosomal disorder, characterized by the presence of additional X chromosomes. Most males with Klinefelter syndrome have 47, XXY and normal intelligence. Intellectual disability occurs in males with Klinefelter syndrome variants, who have a higher number of X chromosomes. Here we report a rare case of a 49, XXXXY syndrome revealed by intellectual deficit and pubertal delay.Observation: An 18...

Introduction: Thyroid-associated orbitopathy is an autoimmune disease of the retroocular tissues commonly associated with Graves’ disease (GD) and rarely reported in Hashimoto’s thyroiditis (HT). GD and HT are autoimmune thyroid disease which are sometimes hard to distinguish from one another and their association in one person is rarely described. Here, we report a case of an exacerbation of thyroid-associated orbitopathy in a patient with GD following a SARS-CoV-2 ...

Introduction: Niemann Pick disease is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in acid sphingomyelinase. Usually discovered in childhood, it can affect liver, spleen and pulmonary function. Here, we report the case of a Niemann Pick type B disease in an adult associated with bilateral adrenal incidentalomas.Observation: A 45-year-old male patient was found to have bilateral adrenal incidentalomas associated with hepato...

Introduction: During the COVID-19 pandemic, an increase of new-onset diabetes has been reported in various diabetes centers with many studies speculating an auto-immune-triggering mechanism while other studies hypothesizing an increase of type 2 diabetes (T2D).Aim: The aim of this study is to compare the type of new-onset diabetes presenting with a diabetic ketoacidosis and its prevalence in the pre-pandemic vs pandemic COVID-19.Me...